Myoglobin-enhanced oxygen delivery to isolated cardiac mitochondria
نویسندگان
چکیده
منابع مشابه
Myoglobin-enhanced oxygen delivery to isolated cardiac mitochondria.
The heart, red skeletal muscles and the nitrogen-fixing legume root nodule function in steady states of high oxygen influx, partial oxygenation of cytoplasmic myoglobin or leghemoglobin and correspondingly low oxygen partial pressure. Here, we ask: what conditions are required at the surface of actively respiring, state III, tightly coupled mitochondria to enhance oxygen flow to cytochrome oxid...
متن کاملMyoglobin-mediated oxygen delivery to mitochondria of isolated cardiac myocytes.
Myoglobin-mediated oxygen delivery to intracellular mitochondria is demonstrated in cardiac myocytes isolated from the hearts of mature rats. Myocytes are held at high ambient oxygen pressure, 40-340 torr (5-45 kPa); sarcoplasmic myoglobin is fully oxygenated. In this condition oxygen availability does not limit respiratory rate; myoglobin-facilitated diffusion contributes no additional oxygen ...
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The most important condition for functioning of all living aerobic organisms is continuous supply of sufficient oxygen. The access of oxygen to metabolic processes in cells is mediated by the respiratory proteins, tetrameric blood hemoglobin (Hb) and monomeric muscle myoglobin (Mb). Myoglobin is expressed in red muscles in response to mitochondrial demand for oxygen, transporting it from sarcol...
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Mitochondrial reactive oxygen species (ROS) have emerged as an important mechanism of disease and redox signaling in the cardiovascular system. Under basal or pathological conditions, electron leakage for ROS production is primarily mediated by the electron transport chain and the proton motive force consisting of a membrane potential (ΔΨ) and a proton gradient (ΔpH). Several factors controllin...
متن کاملMyocardial myoglobin oxygen tension.
COBURN, R. F., F. PLOEGMAKERS, P. GONDRIE, AND R. ABBOUD. Myocardial myoglobin oxygen tension. Am. J. Physiol. 224(4): 870-876. 1973.-We have applied our method of estimating mean myoglobin oxygen tension from measurements of carbon monoxide binding to myoglobin to the in vivo canine myocardium. Carbon monoxide binding to myoglobin was determined with measurements of 14C0 in myocardial biopsy s...
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ژورنال
عنوان ژورنال: Journal of Experimental Biology
سال: 2007
ISSN: 1477-9145,0022-0949
DOI: 10.1242/jeb.003947